Inspiration from the sea for improved wound closure


Researchers from Massachusetts Institute of Technology and Mayo Clinic announce news of a proof-of-concept patch for surgical and emergency situations where stitches or staples would normally be used. Published in the journal Advanced Materials, the patch brings together three technological innovations into what may be a better way to close surgical incisions or tissue damage inside the body.

Barnacles stick to pretty much anything in or near the ocean and come in more than 1,000 species. They feed using a feathery net that extends out from their hard shells when they are submerged in water, collecting a microscopic feast.

As inspiration, the scientists took a trick from one of the world’s clingiest creatures — barnacles. Any tide pooler who has tried to pry a barnacle off a seaside rock can tell you: Don’t bother. Whether on a rocky shore, a whale or a ship, barnacles stay put despite tide and time. At the other end of the spectrum, who hasn’t experienced the frustration of washing and covering a small cut, only to have the sticky bandage immediately fail, sliding off if the area isn’t entirely dry? There’s a reason why stitches or staples are used in surgery where blood and bodily fluids abound. Christoph Nabzdyk, M.D., a Mayo Clinic anesthesiologist and critical care specialist, explains that even so, stitches and staples are to some degree antiquated technologies.

“You have tissue trauma from surgery or due to other insults, and you create more trauma using stitches or staples to approximate the tissue edges,” says Dr. Nabzdyk. “It has been the standard of care, but you’re effectively poking new holes and causing more damage. And it can be difficult if there’s tissue weakness or partial breakdown of tissues, or simply difficult to physically get to. A lot of patients have comorbidities that render them susceptible for impaired healing. So it would be nice to have a device that you can apply without added trauma and have some redundancy if one stitch fails in a suture line.”

This illustration, provided by the researchers, depicts the patch on a surgical stapler. The yellow layer is the silicone oil, which helps the patch move through the body to the place where it will be deployed.

Translating Barnacle Glue to a Surgical Patch

To avoid creating new holes and more trauma, in some cases surgeons can use surgical patching or technologies such as surgical glue. These are not new concepts, but it’s an arena that Dr. Nabzdyk and his colleagues in the lab of Professor Xuanhe Zhao, Ph.D., at Massachusetts Institute of Technology knew could use improvement. In a manuscript posted in December 2020, Dr. Nabzdyk and colleagues, describe how current products tend to be slow to adhere, weak in their ability to bond to tissue, too stiff for some tissues, or unable to be removed without damage to the skin underneath.

Read the rest of the article on Discovery’s Edge.


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